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In the Neelakantan study, diet-induced obese (DIO) C57BL/6 mice were treated with NNMT inhibitors including 5-Amino-1MQ analogues

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In April 2015, another study was published in CMAJ Open that linked PPIs to a threefold increase in the risk of developing acute interstitial nephritis and a higher risk of acute kidney injury in older adults as compared to their peers who did not take the medicines

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